Manchester City and Liverpool shared at Eithad after a pulsating draw.
Mohamed Salah did convert a 13th-minute spot-kick as the reigning Premier League champions struck the first blow in the heavyweight top-flight tussle, putting them on course to sit top of the table during November’s international break.
City, however, weathered the early storm amid the Manchester downpours before countering impressively through Gabriel Jesus, his sixth goal in his past seven league outings.
They could have scored again before half-time had the usually reliable De Bruyne not failed to convert from 12 yards out, the Belgian missing the target completely after another penalty was awarded for handball.
Starting XI: Ederson, Walker, Dias, Laporte, Joao Cancelo, De Bruyne, Rodri, Gundogan, Torres, Gabriel Jesus, Sterling
Subs: Stones, Ake, Zinchenko, Steffen, Bernardo Silva, Foden, Garcia
Starting XI: Alisson, Alexander-Arnold, Matip, Gomez, Robertson, Henderson, Wijnaldum, Salah, Mane, Firmino, Jota
Subs: Milner, Keita, Adrian, Jones, Shaqiri, Origi, Phillips